Lisbon Airport is close to the city, but the final approach matters more than the distance from the runway. A hotel in a steep lane may be delightful after a relaxed afternoon and exhausting after a late flight with bags.
For leisure, pair one historic area with one riverfront or central area and leave time for a café, a viewpoint or an unplanned turn. For work, choose the hotel around the first fixed address, not the most photogenic neighbourhood.