Rome begins before the hotel. A flight may be the only sensible choice for a long-haul journey; for a continuation from a nearby European city, rail can be the calmer and more interesting start. The useful comparison includes the true door-to-door sequence, not simply a departure time or headline fare.
For air travel, Fiumicino and Ciampino should be considered in relation to the origin, arrival time, first address and programme. A late landing, a family arrival, a formal meeting or a table already booked can make the same city feel entirely different.