Two adults on a short cultural break, a family with children, colleagues travelling for a meeting, or someone recovering between long-haul flights do not need the same Rome. The right base begins with the purpose of the stay and the real rhythm of the people in it.
Distance is only one factor. Quiet at night, the character of a street after dinner, lift access, adjoining rooms, breakfast timing, a reliable work space and how the address connects to the first and last movement can matter just as much.